The effect of 1 % atropine solution and 1 % atropine ointment on healing of corneal epithelium in 20 rabbits was studied.
Corneal epithelium was removed by #15 blade in central area of 7mm in diameter under topical anesthesia with 0. 5% pontocaine.
1% atropine solution was applied three times daily to Rt. eyes, and 1% atropine ointment? to Lt. eyes.
Progress of epithelial healing was observed by fluorescent staining of the wound.
At the end. of 24 hours, fluorescent staining area was 46.90% in average for Rt. eyes, and. 51.90% in average for Lt. eyes.
At the end of 48 hours, it was 7.83% for Rt. eyes, and 11.0% for Lt. eyes.
At the end of 72 hours, All of Rt. eyes did not stain, but 2 of 10 Lt. eyes were faintly stained.
Difference between ophthalmic solution and ointment on the effect of corneal epithelial healing was not significant.
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